The definitive marijuana guide from Cannabis UK
Neuromorphological background of cannabis addiction
The expression of central cannabinoid (CB(1)) receptors in tyrosine hydroxylase (TH) containing neurones was demonstrated. Co-localisation was present in different brain areas responsible for reward-related mechanisms. The immunohistochemical investigations have shown that co-localisation is present in parts of mesolimbic-mesocortical dopaminergic system like nucleus accumbens (Nacb), ventral tegmental area (VTA), in the striatum, pyriform cortex, respectively. The results suggest a functional role of CB(1) receptors in cannabis addiction by acting directly on reward-related structures.
Wenger T, Moldrich G, Furst S.